Clinical significance of changes of perioperative T cell and expression of its activatedantigen in colorectal cancer patients.

INTRODUCTION Immune function status is corresponded to genesis and progress of tumor, and cell immune plays a major role in anti-tumor immunity. In recent years, there has been more and more interest in the effect of tumor on functional imbalance of T lymphocyte subgroups. In order to study changes of immune status in colorectal cancer patients before and after operation, we determined six kinds of T lymphocyte surface antigens including CD3, CD4, CD8, CD16, CD69 and CD3/HLA-DR in 35 patients with colorectal cancer from April 1996 to March 1997, and the results were compared with those in patients with benign diseases.